Mediterranean Spaghetti Squash Shrimp Scampi

by | Feb 18, 2022 | Recipes, Dinner

This spaghetti squash shrimp scampi is a delicious and satisfying, low-carb recipe for any night.

We love this recipe because you can toss the squash in the oven to bake while you prepare the rest of the sauce ingredients. The shrimp scampi sauce is made of garlic, butter, red pepper flakes, lemon and a little white wine. Tasty, light, and fresh!

Why We Love Spaghetti Squash 

Spaghetti squash is a great alternative to pasta for its health benefits and taste. It’s a low carbohydrate vegetable, it’s gluten free, and it contains important nutrients. One cup of spaghetti squash contains only about 10 grams of carbohydrates. Spaghetti squash is also a good source of fiber, vitamin C, and B6. If you’ve never made spaghetti squash before, keep reading for a few quick tips!

Eating Fish On The Mediterranean Diet

As recommended by the Dietary Guidelines for Americans, we also suggest eating fish about twice a week. Fish is an important element of the Mediterranean diet and is a good source of protein, vitamins and minerals. Regular consumption of fish is associated with lower cardiovascular disease risk and healthy lipid levels. Shrimp is high in protein, contains healthy unsaturated fats, and minerals like selenium.

What You’ll Need To Make Mediterranean Shrimp Scampi

  • Medium spaghetti squash
  • Unsalted butter
  • Olive oil
  • Garlic cloves
  • Large shrimp
  • Kosher salt
  • Red pepper flakes
  • Pepper
  • Dry white wine or chicken broth
  • Lemon (zest, juice, & slices)
  • Baby spinach
  • Fresh parsley leaves
  • Parmesan cheese

Is There An Easy Way To Cut Open A Spaghetti Squash?

Spaghetti squash can seem intimidating at first, but you’ll be an expert in no time. You can cut the spaghetti squash lengthwise with a sharp kitchen knife. If the shell is thick and troublesome to cut, try this! Pierce the squash a few times with the knife to allow steam to escape, then place the squash in the microwave for about 3 minutes. This will soften it enough to cut more easily. Then return to the lengthwise cut and bake as indicated below.

How To Cook Spaghetti Squash Shrimp Scampi

Baking Spaghetti Squash

Preheat the oven to 400F and prepare your spaghetti squash. Begin by cutting the squash lengthwise and discarding the seeds. Set the squash face down in a baking dish and add in a splash of water to cover the bottom. Bake for 35-45 minutes. When the squash is done cooking it should be a little soft. Using a fork, begin to pull strands from the edges to the center, turning it to a spaghetti texture.

Preparing the Shrimp Scampi Sauce

Combine butter and oil in a pan over medium heat. Sauté garlic on its own for a minute then add shrimp, salt, red pepper flakes, and pepper. Cook for about 3 minutes until the shrimp is pink. Add white wine and lemon to the pan to boil. And finally, add in the spaghetti squash to combine with the sauce and shrimp. Top with parmesan and parsley!

Fully Mediterranean logo
mediterranean spaghetti squash shrimp scampi fully mediterranean
Lemon and garlic shrimp scampi served over baked spaghetti squash for a tasty low-carb dinner.
Course Dinner, Main Course
Servings 3 servings
Cuisine Italian, Mediterranean
Diet Gluten Free


  • Baking sheet
  • Nonstick Pan
  • Large Bowl


  • 1 medium spaghetti squash
  • 1 Tablespoon unsalted butter
  • 2 Tablespoons olive oil
  • 5 cloves garlic minced
  • 1 pound large shrimp peeled and deveined
  • 1 teaspoon kosher salt
  • ½ -1 teaspoon red pepper flakes
  • ¼ teaspoon pepper
  • ¼ cup dry white wine or chicken broth
  • 1 lemon thinly sliced in half rounds
  • Grated zest of 1 lemon
  • Juice of 2 lemons
  • 3 cups baby spinach
  • 2 tbsp Garnish: fresh parsley leaves chopped
  • Parmesan cheese


  • Preheat the oven to 400°F.
  • Cut the squash in half lengthwise and scoop out the seeds with a spoon, discard.
  • Place the halves, flesh side down in a 13 X 9 pyrex dish and pour a little water around the squash to cover the bottom of the dish.
  • Bake for 35-45 minutes depending on the size of the squash. The squash is ready when the flesh can be easily scraped with a fork.
  • Scrape the inside of the squash with a fork to remove spaghetti- like strands. Place in a large bowl and set aside.
  • Heat the butter and olive oil in a nonstick pan over medium heat. Add garlic and saute for 1 minute. Add shrimp, salt, red pepper flakes and pepper. Continue to cook, stirring often for a couple of minutes until shrimp turn pink, around 3-4 minutes.
  • Add white wine, lemon zest, lemon juice and lemon slices. Bring to a boil and continue to cook for 1 minute. Add the spinach and stir. Add the spaghetti squash noodles and toss with shrimp. Cook for another minute or two until heated through.
  • Remove from heat, add parsley and parmesan and toss. Season with salt and pepper if desired. Enjoy!
Tried and loved this recipe?Tag us @fullymediterranean!

Interested To Try More Spaghetti Squash Recipes?

Check out our favorites that are just as good as this spaghetti squash shrimp scampi: